PMS2 antibody (Middle Region)

Catalog No. ABIN2786522

The Rabbit Polyclonal anti-PMS2 antibody (ABIN2786522) specifically detects PMS2 in WB. The antibody is reactive with Human, Rat, Cow, Guinea Pig, Dog, Horse, Rabbit and Saccharomyces cerevisiae samples.

Quick Overview for PMS2 antibody (Middle Region) (ABIN2786522)

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Reactivity: Human, Rat, Cow, Guinea Pig, Dog, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PMS2 Antibody

Binding Specificity: Middle Region

Purpose: PMS2 Antibody - middle region

Sequence: INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Rabbit: 92%, Rat: 92%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against PMS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PMS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56117-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PMS2

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Alternative Name: PMS2

Background:

Background Information: PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Gene Name: PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

Alternative Symbols: MLH4, PMSL2, HNPCC4, MMRCS4, PMS2CL

Protein Name: Mismatch repair endonuclease PMS2

Molecular Weight: 96kDa

Gene ID: 5395

NCBI Accession: NP_000526

UniProt: P54278

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response