PSMD3 antibody (Middle Region)
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- Target See all PSMD3 Antibodies
- PSMD3 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 (PSMD3))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PSMD3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- YSTREPQLAF HQRISFCLDI HNMSVKAMRF PPKSYNKDLE SAEERREREQ
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against PSMD3. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PSMD3
- Top Product
- Discover our top product PSMD3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 534 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PSMD3 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 (PSMD3))
- Alternative Name
- PSMD3 (PSMD3 Products)
- Synonyms
- P58 antibody, RPN3 antibody, S3 antibody, TSTA2 antibody, AI255837 antibody, AntP91a antibody, D11Bwg1349e antibody, Psd3 antibody, Tstap91a antibody, proteasome 26S subunit, non-ATPase 3 antibody, proteasome 26S subunit, non-ATPase 3 S homeolog antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 antibody, 26S proteasome non-ATPase regulatory subunit 3 antibody, PSMD3 antibody, psmd3.S antibody, Psmd3 antibody, rpn-3 antibody
- Background
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.
Alias Symbols: P58, RPN3, S3, TSTA2
Protein Interaction Partner: CEP44, ZBTB43, HUWE1, SHFM1, SPRTN, SNAI2, STAU1, PSMD14, UBC, UBQLN1, FLNC, FLNB, PSMD8, PSMD4, PSMD1, PSMC6, PSMC5, PSMC4, PSMC3, PSMC2, PSMC1, KCMF1, UCHL5, KIAA0368, ADRM1, TXNL1, SQSTM1, RPS28, RPS21, RPS15A, RPS13, RPS8, PSMD12, PSMD11, PARK2, FBXO6
Protein Size: 534 - Molecular Weight
- 61 kDa
- Gene ID
- 5709
- NCBI Accession
- NM_002809, NP_002800
- UniProt
- O43242
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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