PNPLA8 antibody (Middle Region)

Catalog No. ABIN504075

Cited in 1 publication. The Rabbit Polyclonal anti-PNPLA8 antibody (ABIN504075) specifically detects PNPLA8 in WB. The antibody is reactive with Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio) samples.

Quick Overview for PNPLA8 antibody (Middle Region) (ABIN504075)

Target: PNPLA8 (Patatin-Like phospholipase Domain Containing 8 (PNPLA8))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNPLA8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PNPLA8 Antibody

Binding Specificity: Middle Region

Purpose: PNPLA8 Antibody - middle region

Sequence: IDNRTRALVQ ALRRTTDPKL CITRVEELTF HLLEFPEGKG VAVKERIIPY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against PNPLA8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PNPLA8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56759-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PNPLA8 antibody (ABIN504075)

Ali, Kokotos, Magrioti, Bone, Mobley, Hancock, Ramanadham: "Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes." in: PLoS ONE, Vol. 8, Issue 8, pp. e71748, (2013) (PubMed).

Target Details for PNPLA8

Target: PNPLA8 (Patatin-Like phospholipase Domain Containing 8 (PNPLA8))

Alternative Name: PNPLA8

Background:

Background Information: Phospholipase A2 catalyzes cleavage of fatty acids from phospholipids, thereby regulating membrane physical properties and the release of lipid second messengers and growth factors. Phospholipase A2 activity also modulates cellular growth programs, inflam

Gene Name: Patatin-like phospholipase domain containing 8

Alternative Symbols: MMLA, IPLA2G, IPLA2-2, iPLA2gamma, PNPLA-gamma

Protein Name: Calcium-independent phospholipase A2-gamma

Molecular Weight: 88 kDa

Gene ID: 50640

NCBI Accession: NP_056538

UniProt: Q9NP80