SHC3 antibody (N-Term)

Catalog No. ABIN2786991

The Rabbit Polyclonal anti-SHC3 antibody is suitable to detect SHC3 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for SHC3 antibody (N-Term) (ABIN2786991)

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SHC3 Antibody

Binding Specificity: N-Term

Sequence: PSKMLSSILG KSNLQFAGMS ISLTISTASL NLRTPDSKQI IANHHMRSIS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Shc3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 474 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SHC3

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Alternative Name: Shc3

Background: Shc3 is a signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. It is involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Alias Symbols: MGC124163, N-Shc, Rai, ShcC
Protein Interaction Partner: Src, Grin2b, Grin1, Axl, Egfr, Ntrk1,
Protein Size: 474

Molecular Weight: 52 kDa

Gene ID: 20418

NCBI Accession: NM_009167, NP_033193

UniProt: Q61120

Pathways: RTK Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway