PLAT antibody (Middle Region)

Catalog No. ABIN2787342

The Rabbit Polyclonal anti-PLAT antibody has been validated for WB. It is suitable to detect PLAT in samples from Human, Mouse, Rat, Pig, Rabbit, Cow, Guinea Pig, Dog and Horse.

Quick Overview for PLAT antibody (Middle Region) (ABIN2787342)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Cow, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAT Antibody

Binding Specificity: Middle Region

Sequence: TVILGRTYRV VPGEEEQKFE VEKYIVHKEF DDDTYDNDIA LLQLKSDSSR

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 82%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PLAT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PLAT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 516 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: PLAT

Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Alias Symbols: DKFZp686I03148, T-PA, TPA
Protein Interaction Partner: PDGFC, POT1, TERF2, CKAP4, LRP1B, GRIN1, SERPING1, SERPINI1, SERPINA5, MAPK3, LAMA3, F10, PLAU, CLEC3B, SPARC, MAPK1, PLAT, SERPINE1, PLG, HMGB1, ANXA2, LAMA1, KRT8, FGA, CALR, LRP1, FN1, LAMA5, F2,
Protein Size: 516

Molecular Weight: 53 kDa

Gene ID: 5327

NCBI Accession: NM_033011, NP_127509

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome