RAD51 Homolog B antibody (Middle Region)

Catalog No. ABIN2787357

This anti-RAD51 Homolog B antibody is a Rabbit Polyclonal antibody detecting RAD51 Homolog B in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit and Horse.

Quick Overview for RAD51 Homolog B antibody (Middle Region) (ABIN2787357)

Target: RAD51 Homolog B (Rad51B)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51 Homolog B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RAD51 Homolog B Antibody

Binding Specificity: Middle Region

Sequence: TESAFSAERL VEIAESRFPR YFNTEEKLLL TSSKVHLYRE LTCDEVLQRI

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 79%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against RAD51L1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RAD51L1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 350 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RAD51 Homolog B

Target: RAD51 Homolog B (Rad51B)

Alternative Name: RAD51L1

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: MGC34245, R51H2, RAD51B, REC2, hREC2, RAD51L1
Protein Interaction Partner: FAM9B, SWSAP1, UBC, HIST1H2BG, HIST2H4A, RAD51D, HIST1H3A, RAD51C, H1F0, XRCC2, RAD51, HIST1H1A, HIST3H2BB, HIST3H3, HIST4H4,
Protein Size: 350

Molecular Weight: 38 kDa

Gene ID: 5890

NCBI Accession: NM_133510, NP_598194

Pathways: DNA Damage Repair