PCSK6 antibody (N-Term)

Catalog No. ABIN2787440

This Rabbit Polyclonal antibody specifically detects PCSK6 in WB. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Dog, Cow, Horse, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for PCSK6 antibody (N-Term) (ABIN2787440)

Target: PCSK6 (Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6))

Reactivity: Human, Rat, Mouse, Rabbit, Dog, Cow, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PCSK6 Antibody

Binding Specificity: N-Term

Sequence: NYDSYASYDV NGNDYDPSPR YDASNENKHG TRCAGEVAAS ANNSYCIVGI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PCSK6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCSK6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 975 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCSK6

Target: PCSK6 (Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6))

Alternative Name: PCSK6

Background: PCSK6 is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. This gene is thought to play a role in tumor progression.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: PACE4, SPC4
Protein Interaction Partner: env, UBC, CACNA1A, RCN3, FLG, PMCH, PCSK6,
Protein Size: 975

Molecular Weight: 91 kDa

Gene ID: 5046

NCBI Accession: NM_138320, NP_612193

UniProt: Q63415

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome