TCF7L1 antibody (N-Term)

Catalog No. ABIN2787453

This Rabbit Polyclonal antibody specifically detects TCF7L1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog and Rabbit.

Quick Overview for TCF7L1 antibody (N-Term) (ABIN2787453)

Target: TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF7L1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TCF7L1 Antibody

Binding Specificity: N-Term

Sequence: ESENQSSSSD SEAERRPQPV RDTFQKPRDY FAEVRRPQDS AFFKGPPYPG

Predicted Reactivity: Cow: 86%, Dog: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against TCF7L1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 588 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TCF7L1

Target: TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1))

Alternative Name: TCF7L1

Background: TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.
Alias Symbols: TCF-3, TCF3
Protein Interaction Partner: UBC, mdfic, Mdfi, DAZAP2, CTNNB1,
Protein Size: 588

Molecular Weight: 63 kDa

Gene ID: 83439

NCBI Accession: NM_031283, NP_112573

UniProt: Q9HCS4

Pathways: WNT Signaling, Stem Cell Maintenance