Metabotropic Glutamate Receptor 6 antibody (N-Term)

Catalog No. ABIN2787505

The Rabbit Polyclonal anti-Metabotropic Glutamate Receptor 6 antibody is suitable to detect Metabotropic Glutamate Receptor 6 in samples from Human, Rat, Mouse, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Pig and Sheep. It has been validated for WB.

Quick Overview for Metabotropic Glutamate Receptor 6 antibody (N-Term) (ABIN2787505)

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Reactivity: Human, Rat, Mouse, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Metabotropic Glutamate Receptor 6 Antibody

Binding Specificity: N-Term

Purpose: GRM6 Antibody - N-terminal region

Sequence: AGGLTLGGLF PVHARGAAGR ACGQLKKEQG VHRLEAMLYA LDRVNADPEL

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 100%, Rat: 93%, Sheep: 79%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against GRM6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GRM6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58004-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Metabotropic Glutamate Receptor 6

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Alternative Name: GRM6

Background:

Background Information: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Gene Name: Glutamate receptor, metabotropic 6

Alternative Symbols: mGlu6, CSNB1B, GPRC1F, MGLUR6

Protein Name: Metabotropic glutamate receptor 6

Molecular Weight: 95kDa

Gene ID: 2916

NCBI Accession: NP_000834

UniProt: O15303