POT1 antibody (Middle Region)

Catalog No. ABIN2787632

The Rabbit Polyclonal anti-POT1 antibody (ABIN2787632) specifically detects POT1 in WB. The antibody is reactive with Human, Mouse, Rat, Guinea Pig, Dog, Horse, Cow, Pig, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for POT1 antibody (Middle Region) (ABIN2787632)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse, Cow, Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-POT1 Antibody

Binding Specificity: Middle Region

Purpose: POT1 Antibody - middle region

Sequence: MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against POT1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POT1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58317-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Alternative Name: POT1

Background:

Background Information: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Gene Name: Protection of telomeres 1 homolog (S. pombe)

Alternative Symbols: GLM9, CMM10, HPOT1

Protein Name: Protection of telomeres protein 1

Molecular Weight: 70kDa

Gene ID: 25913

NCBI Accession: NP_056265

UniProt: Q9NUX5

Pathways: Cell Division Cycle, Telomere Maintenance