This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. Alias Symbols: EK4, ETK, ETK1, HEK, HEK4, TYRO4 Protein Interaction Partner: UBC, CDKN2A, SRPK1, RBM18, RUFY1, RUFY2, EFNA2, ADAM10, EFNA5, EFNB2, TP53, EFNA1, EPHA3, PIM1, CRK, STAT3, ABL1, SRC, FYN, EFNB1, EFNA4, EFNA3, Protein Size: 539