BNIP3L/NIX antibody (Middle Region)

Catalog No. ABIN2787863

The Rabbit Polyclonal anti-BNIP3L/NIX antibody is suitable to detect BNIP3L/NIX in samples from Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Pig and Rabbit. It has been validated for WB.

Quick Overview for BNIP3L/NIX antibody (Middle Region) (ABIN2787863)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BNIP3L/NIX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BNIP3L/NIX Antibody

Binding Specificity: Middle Region

Purpose: Bnip3l Antibody - middle region

Sequence: CDSPSPQEDG QIMFDVEMHT SRDHSSQSEE EVVEGEKEVE ALKKSADWVS

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Bnip3l. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58878-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: Bnip3l

Background:

Background Information: Bnip3l induces apoptosis. It interacts with viral and cellular anti-apoptosis proteins. It can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. It inhibits apoptosis induced by BNIP3. It is involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. Bnip3l may function as a tumor suppressor.

Gene Name: BCL2/adenovirus E1B interacting protein 3-like

Alternative Symbols: N, Nix, Nip3L, C86132, D14Ertd719, D14Ertd719e

Protein Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Molecular Weight: 24kDa

Gene ID: 12177

NCBI Accession: NP_033891

UniProt: Q9Z2F7

Pathways: Autophagy