AXL antibody (C-Term)

Catalog No. ABIN2787910

Product Details anti-AXL Antibody

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXL antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QPDPKDSCSC LTAAEVHPAG RYVLCPSTTP SPAQPADRGS PAAPGQEDGA

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 85%, Pig: 86%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against AXL. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AXL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 885 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AXL

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Alternative Name: AXL (AXL Products)

Background: The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: JTK11, UFO
Protein Interaction Partner: RANBP9, UBC, TYRO3, FBXO25, STUB1, HSP90AA1, HSPA1A, ERRFI1, TNK2, ELAVL1, CBL, SHC3, SOCS1, PIK3R2, ADAM10, SHC1, GAS6, SRC, PTPN11, PLCG1, PIK3R1, LCK, AXL, GRB2, TENC1, PIK3R3, NCK2,
Protein Size: 885

Molecular Weight: 97 kDa

Gene ID: 558

NCBI Accession: NM_001699, NP_001690

UniProt: P30530

Pathways: RTK Signaling, Cellular Response to Molecule of Bacterial Origin