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IL7R antibody (Interleukin 7 Receptor) (Middle Region) Primary Antibody

IL7R Reactivity: Human, Dog, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2787929
$389.00
Plus shipping costs $45.00
100 μL
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  • Target
    IL7R
    Binding Specificity
    • 22
    • 10
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 105
    • 73
    • 18
    • 7
    • 5
    • 1
    • 1
    Human, Dog, Horse
    Host
    • 88
    • 29
    • 24
    • 7
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 92
    • 61
    Polyclonal
    Conjugate
    • 64
    • 12
    • 11
    • 10
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL7R antibody is un-conjugated
    Application
    • 74
    • 58
    • 53
    • 26
    • 16
    • 11
    • 10
    • 9
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP
    Predicted Reactivity
    Dog: 92%, Horse: 83%, Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against IL7R. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human IL7R
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 459 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    IL7R
    Alternative Name
    IL7R (IL7R Antibody Abstract)
    Synonyms
    IL7R, CD127, IL-7Ralpha, CDW127, IL-7R-alpha, IL7RA, ILRA, IL-7RA, interleukin 7 receptor, IL7R, Il7r
    Background
    The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
    Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
    Protein Interaction Partner: KIT, JAK3, SNRPG, SNRPD3, SNRPD2, SNRPD1, SNRPB, SNRPA, SNRNP70, SRSF3, SAFB, RPS20, RPS3, RPL31, RPL29, RPL30, RPL22, RPL18, RPL15, RPL8, RPL7, RPL6, RBM3, PURB, PURA, PTMA, PTBP1, EIF2AK2, YBX1, NONO, NCL, MAP4, RPSA, ILF3, ILF2, HNRNPU, HNRNPL, HNRNPH3
    Protein Size: 459
    Molecular Weight
    49 kDa
    Gene ID
    3575
    NCBI Accession
    NM_002185, NP_002176
    UniProt
    P16871
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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