CD4 antibody (C-Term)

Catalog No. ABIN2787938

This Rabbit Polyclonal antibody specifically detects CD4 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Rabbit, Cow, Sheep, Guinea Pig, Goat and Horse.

Quick Overview for CD4 antibody (C-Term) (ABIN2787938)

Target: CD4

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Sheep, Guinea Pig, Goat, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD4 Antibody

Binding Specificity: C-Term

Sequence: VLGGVAGLLL FIGLGIFFCV RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against CD4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CD4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 458 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD4

Target: CD4

Alternative Name: CD4

Background: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Alias Symbols: CD4mut
Protein Interaction Partner: env, RANBP9, vpu, ADRB2, UBC, CXCR4, UBL7, ABCB1, INPPL1, VCP, HGS, LCK, NR3C1, STUB1, TUBB, MYL12A, DHRS2, LRPPRC, FARSB, EIF3I, EIF3D, EIF3C, EIF3B, VIM, VDAC3, VDAC2, VDAC1, SSRP1, RPS19, RPS12, RPS10, RPS9, RPLP1, RPLP0, RPL22, RPL18, RPL7, PHB, NPM1,
Protein Size: 458

Molecular Weight: 48 kDa

Gene ID: 920

NCBI Accession: NM_000616, NP_000607

UniProt: P01730

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events