LAG3 antibody (C-Term)

Catalog No. ABIN2787950

The Rabbit Polyclonal anti-LAG3 antibody (ABIN2787950) specifically detects LAG3 in WB. The antibody is reactive with Human, Mouse, Rat, Rabbit and Saccharomyces cerevisiae samples.

Quick Overview for LAG3 antibody (C-Term) (ABIN2787950)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reactivity: Human, Mouse, Rat, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAG3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LAG3 Antibody

Binding Specificity: C-Term

Purpose: LAG3 Antibody - C-terminal region

Sequence: GFHLWRRQWR PRRFSALEQG IHPPQAQSKI EELEQEPEPE PEPEPEPEPE

Predicted Reactivity: Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against LAG3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human LAG3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59142-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Alternative Name: LAG3

Background:

Background Information: Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Gene Name: Lymphocyte-activation gene 3

Alternative Symbols: CD223

Protein Name: Lymphocyte activation gene 3 protein

Molecular Weight: 55kDa

Gene ID: 3902

NCBI Accession: NP_002277

UniProt: P18627

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints