NUMB antibody (C-Term)

Catalog No. ABIN2788064

This Rabbit Polyclonal antibody specifically detects NUMB in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Cow and Pig.

Quick Overview for NUMB antibody (C-Term) (ABIN2788064)

Target: NUMB (Numb Homolog (NUMB))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NUMB Antibody

Binding Specificity: C-Term

Purpose: Numb Antibody - C-terminal region

Sequence: ASGNRHAEVP PGTCPVDPFE AQWAALESKS KQRTNPSPTN PFSSDLQKTF

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Numb. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59433-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: Numb

Background:

Background Information: Numb plays a role in the process of neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. It is not required for the proliferation of neural progenitor cells before the onset of neurogenesis. It is also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. It may also mediate local repair of brain ventricular wall damage.

Gene Name: Numb gene homolog (Drosophila)

Alternative Symbols: Nb, m-num

Protein Name: Protein numb homolog

Molecular Weight: 66kDa

Gene ID: 18222

NCBI Accession: NP_035079

UniProt: Q9QZS3

Pathways: Cell-Cell Junction Organization