NUMB antibody (C-Term)
-
- Target See all NUMB Antibodies
- NUMB (Numb Homolog (NUMB))
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This NUMB antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- ASGNRHAEVP PGTCPVDPFE AQWAALESKS KQRTNPSPTN PFSSDLQKTF
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against Numb. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product NUMB Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 604 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- NUMB (Numb Homolog (NUMB))
- Alternative Name
- Numb (NUMB Products)
- Synonyms
- C14orf41 antibody, S171 antibody, c14_5527 antibody, Nb antibody, NUMB, endocytic adaptor protein antibody, numb homolog (Drosophila) antibody, NUMB antibody, Numb antibody, numb antibody
- Background
-
Numb plays a role in the process of neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. It is not required for the proliferation of neural progenitor cells before the onset of neurogenesis. It is also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. It may also mediate local repair of brain ventricular wall damage.
Alias Symbols: m-numb, mnb, m-Nb
Protein Interaction Partner: Igsf5, Eed, Grin1, Cdh2, Cdh1, Ctnnb1, Ctnna1, Lnx2, Lnx1, Notch1, Eps15, Ehd1, Ehd4,
Protein Size: 604 - Molecular Weight
- 66 kDa
- Gene ID
- 18222
- NCBI Accession
- NM_010949, NP_035079
- Pathways
- Cell-Cell Junction Organization
-