NUMB antibody (Middle Region)

Catalog No. ABIN2788065

This anti-NUMB antibody is a Rabbit Polyclonal antibody detecting NUMB in WB. Suitable for Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Saccharomyces cerevisiae and Zebrafish (Danio rerio).

Quick Overview for NUMB antibody (Middle Region) (ABIN2788065)

Target: NUMB (Numb Homolog (NUMB))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NUMB Antibody

Binding Specificity: Middle Region

Sequence: VGSSVAPGNT APSPSSPTSP TSDATTSLEM NNPHAIPRRH APIEQLARQG

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against NUMB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human NUMB

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: NUMB

Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: TP53, PRKCA, PRKCZ, PRKCE, PRKCB, UBC, SIAH1, RPL3, EGFR, NOTCH1, MDM2, APP, Trp53, Jun, EPS15, Lnx1, ITCH, GLI1, LNX2, AP2A2, PRKCH, DPYSL2, AP2A1, ITGB2, L1CAM, PRKCG, PRKCD, ITGB3, ITGB5, Eps15l1, RALBP1,
Protein Size: 592

Molecular Weight: 64 kDa

Gene ID: 8650

Pathways: Cell-Cell Junction Organization