NUMB antibody (Middle Region)

Catalog No. ABIN2788065

Product Details anti-NUMB Antibody

Target: NUMB (Numb Homolog (NUMB))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VGSSVAPGNT APSPSSPTSP TSDATTSLEM NNPHAIPRRH APIEQLARQG

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against NUMB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human NUMB

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: NUMB (NUMB Products)

Synonyms: C14orf41 antibody, S171 antibody, c14_5527 antibody, Nb antibody, NUMB, endocytic adaptor protein antibody, numb homolog (Drosophila) antibody, NUMB antibody, Numb antibody, numb antibody

Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: TP53, PRKCA, PRKCZ, PRKCE, PRKCB, UBC, SIAH1, RPL3, EGFR, NOTCH1, MDM2, APP, Trp53, Jun, EPS15, Lnx1, ITCH, GLI1, LNX2, AP2A2, PRKCH, DPYSL2, AP2A1, ITGB2, L1CAM, PRKCG, PRKCD, ITGB3, ITGB5, Eps15l1, RALBP1,
Protein Size: 592

Molecular Weight: 64 kDa

Gene ID: 8650

Pathways: Cell-Cell Junction Organization