Metabotropic Glutamate Receptor 3 antibody (C-Term)

Catalog No. ABIN2788133

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 3 in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Horse, Rabbit and Dog.

Quick Overview for Metabotropic Glutamate Receptor 3 antibody (C-Term) (ABIN2788133)

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reactivity: Human, Rat, Mouse, Cow, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Metabotropic Glutamate Receptor 3 Antibody

Binding Specificity: C-Term

Purpose: GRM3 Antibody - C-terminal region

Sequence: RDFWEQKFQC SLQNKRNHRR VCDKHLAIDS SNYEQESKIM FVVNAVYAMA

Predicted Reactivity: Cow: 92%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against GRM3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human GRM3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59603-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Metabotropic Glutamate Receptor 3

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Alternative Name: GRM3

Background:

Background Information: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Gene Name: glutamate receptor, metabotropic 3

Alternative Symbols: GLUR3, mGlu3, GPRC1C, MGLUR3

Protein Name: metabotropic glutamate receptor 3

Molecular Weight: 59kDa

Gene ID: 2913

NCBI Accession: NP_000831

UniProt: Q14832

Pathways: cAMP Metabolic Process, Synaptic Membrane