GTP Cyclohydrolase 1 (GCH1) (N-Term) antibody

Details for Product No. ABIN2788139, Supplier: Log in to see
Antigen
  • DYT14
  • DYT5
  • DYT5a
  • GCH
  • GTP-CH-1
  • GTPCH1
  • HPABH4B
  • GTP-CH
  • GTPCH
  • Gch
  • MGC89622
  • gch1a
  • wu:fc16b10
  • zgc:195269
  • GTP cyclohydrolase 1
  • GTP cyclohydrolase 1-like
  • GCH1
  • Gch1
  • gch1
  • Weevi_1190
  • Halhy_0838
  • Sinme_1220
  • Sphch_1077
  • LOC100136794
Epitope
N-Term
15
11
11
9
8
7
5
3
2
2
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Rabbit, Rat (Rattus)
80
31
31
4
4
3
3
3
2
2
2
2
2
1
1
1
Host
Rabbit
54
16
12
Clonality
Polyclonal
Conjugate
Un-conjugated
7
6
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
65
46
24
13
8
7
6
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen The immunogen is a synthetic peptide directed towards the N-terminal region of Human GCH1
Blocking Peptide Blocking peptide for this product available: ABIN2185568
Sequence PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR
Predicted Reactivity Cow: 100%, Dog: 100%, Human: 100%, Rabbit: 100%, Rat: 86%
Characteristics This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.
Purification Affinity Purified
Alternative Name GCH1 (GCH1 Antibody Abstract)
Background This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Protein Interaction Partner: GCH1, CALML6, CAMKK1, CSNK1G1, CALML5, PACSIN3, RGS19, MAP2K4, MAPK12, MAP2K5, MAPK10, PRKAR2B, PRKAR2A, PPM1B, CSNK2B, CSNK2A1, GIT2, YWHAZ, CNRIP1, RAB26, AHSA1, SP3, RLF, HSPA8, GCHFR, ATP1B1, CDC37, SH3GL2, OSBPL9, RPH3A,
Protein Size: 250
Molecular Weight 27 kDa
Gene ID 2643
UniProt P30793
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeat freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-GTP Cyclohydrolase 1 (GCH1) (N-Term) antibody (ABIN2788139) Host: Rabbit Target Name: GCH1 Sample Tissue: Human Fetal Heart Antibody Dilution: 1u...
Did you look for something else?