Calnexin antibody (C-Term)

Catalog No. ABIN2788198

The Rabbit Polyclonal anti-Calnexin antibody has been validated for WB. It is suitable to detect Calnexin in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Horse and Zebrafish (Danio rerio).

Quick Overview for Calnexin antibody (C-Term) (ABIN2788198)

Target: Calnexin (CANX)

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calnexin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Calnexin Antibody

Binding Specificity: C-Term

Sequence: RPWLWVVYIL TVALPVFLVI LFCCSGKKQT SGMEYKKTDA PQPDVKEEEE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against CANX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CANX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 592 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Calnexin

Target: Calnexin (CANX)

Alternative Name: CANX

Background: This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.
Alias Symbols: CNX, FLJ26570, IP90, P90
Protein Interaction Partner: ERLIN2, HUWE1, UBC, TRAF6, SUMO2, TOR1A, STAU1, MDM2, LGR4, WWOX, NPHS1, RPA3, RPA2, RPA1, SUZ12, RNF2, BMI1, FBXO6, PTGIR, ADRB2, PDIA3, CLN5, YIPF3, SMURF2, env, PGRMC1, BCAP31, UBL4A, SERPINA1, MTNR1A, CSNK2A1, ATF2, CFTR, VCP, PKD2, LDLR, ASGR1, KCNH2
Protein Size: 592

Molecular Weight: 65 kDa

Gene ID: 821

NCBI Accession: NM_001746, NP_001737

UniProt: P27824

Pathways: MAPK Signaling, Thyroid Hormone Synthesis