GADD45A antibody (C-Term)
Quick Overview for GADD45A antibody (C-Term) (ABIN2788360)
Target
See all GADD45A AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- C-Term
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Sequence
- LRVSNPGRLA ELLLLETDAG PAASEGAEQP PDLHCVLVTN PHSSQWKDPA
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Predicted Reactivity
- Cow: 100%, Horse: 79%, Human: 100%, Pig: 93%, Rabbit: 86%
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Characteristics
- This is a rabbit polyclonal antibody against GADD45A. It was validated on Western Blot.
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Purification
- Affinity Purified
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Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human GADD45A
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Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
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Comment
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Antigen size: 165 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A))
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Alternative Name
- GADD45A
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Background
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GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of GADD45A gene is mediated by both p53-dependent and -independent mechanisms.
Alias Symbols: DDIT1, GADD45
Protein Interaction Partner: ING4, UBC, AURKA, STAT3, PCNA, MTOR, CDK1, APEX1, DCTN2, RPS7, MDM2, MAPK1, TIAL1, HNRNPA0, SH3GLB1, PTPRK, PSMC3, NUCB2, CDK11A, ASCC2, FAS, CCNB1, DNMT1, JMJD1C, UBR1, SYNE4, MIDN, IGSF21, FBN3, FAM83D, MICAL1, SPTBN4, NRBP1, DNAJC13, ZHX1, C14orf1, ADA
Protein Size: 165 -
Molecular Weight
- 18 kDa
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Gene ID
- 1647
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NCBI Accession
- NM_001924, NP_001915
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UniProt
- P24522
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Pathways
- p53 Signaling, Cell Division Cycle
Target
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