MAPKAP Kinase 3 antibody (C-Term)

Catalog No. ABIN2788402

Product Details anti-MAPKAP Kinase 3 Antibody

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP Kinase 3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KEEMTSALAT MRVDYDQVKI KDLKTSNNRL LNKRRKKQAG SSSASQGCNN

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MAPKAPK3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MAPKAPK3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 382 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPKAP Kinase 3

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Alternative Name: MAPKAPK3 (MAPKAPK3 Products)

Synonyms: 3PK antibody, MAPKAP-K3 antibody, MAPKAP3 antibody, MAPKAPK-3 antibody, MK-3 antibody, AI874665 antibody, MK3 antibody, MapkKapk3 antibody, MAPKAPK3 antibody, mapkapk3 antibody, MGC154360 antibody, 3pk antibody, mapkap3 antibody, zgc:158342 antibody, mitogen-activated protein kinase-activated protein kinase 3 antibody, mitogen-activated protein kinase-activated protein kinase 3 S homeolog antibody, MAPKAPK3 antibody, Mapkapk3 antibody, mapkapk3.S antibody, mapkapk3 antibody

Background: MAPKAPK3 is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
Alias Symbols: 3PK, MAPKAP3, MK-3, MAPKAP-K3, MAPKAPK-3
Protein Interaction Partner: UBC, TCF3, MAPK11, MAPK14, HSPB1, APP, LNX1, RNF2, PHC2, BMI1, Nedd4, NEDD4L, COPS6, SUMO3, SMS, RAB2A, IGHM, EZH2, MAPK13, EEF2K, EEF2, CBX4,
Protein Size: 382

Molecular Weight: 43 kDa

Gene ID: 7867

NCBI Accession: NM_004635, NP_004626

UniProt: Q16644

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades