MAPKAP Kinase 3 antibody (C-Term)

Catalog No. ABIN2788402

The Rabbit Polyclonal anti-MAPKAP Kinase 3 antibody (ABIN2788402) specifically detects MAPKAP Kinase 3 in WB. The antibody is reactive with Human, Mouse, Rat, Pig, Rabbit, Guinea Pig, Horse, Cow and Dog samples.

Quick Overview for MAPKAP Kinase 3 antibody (C-Term) (ABIN2788402)

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP Kinase 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPKAP Kinase 3 Antibody

Binding Specificity: C-Term

Purpose: MAPKAPK3 Antibody - C-terminal region

Sequence: KEEMTSALAT MRVDYDQVKI KDLKTSNNRL LNKRRKKQAG SSSASQGCNN

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MAPKAPK3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MAPKAPK3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60321-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPKAP Kinase 3

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Alternative Name: MAPKAPK3

Background:

Background Information: MAPKAPK3 is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Gene Name: Mitogen-activated protein kinase-activated protein kinase 3

Alternative Symbols: 3PK, MK3, MK-3, MDPT3, MAPKAP3, MAPKAP-K3, MAPKAPK-3

Protein Name: MAP kinase-activated protein kinase 3

Molecular Weight: 43kDa

Gene ID: 7867

NCBI Accession: NP_004626

UniProt: Q16644

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades