MAPKSP1 antibody (N-Term)

Catalog No. ABIN2788404

The Rabbit Polyclonal anti-MAPKSP1 antibody (ABIN2788404) specifically detects MAPKSP1 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for MAPKSP1 antibody (N-Term) (ABIN2788404)

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKSP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPKSP1 Antibody

Binding Specificity: N-Term

Sequence: LPSVEGLHAI VVSDRDGVPV IKVANDNAPE HALRPGFLST FALATDQGSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against LAMTOR3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human LAMTOR3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPKSP1

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Alternative Name: LAMTOR3

Background: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
Alias Symbols: MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
Protein Interaction Partner: NIF3L1, LAMTOR2, IBTK, MBD2, BHMT, PEF1, C19orf70, MRPL43, PRR3, LPCAT1, MRPS9, MRPS35, MRPL47, TOMM22, DDX28, TSR1, RNMTL1, LAMTOR1, NDUFB11, TMCO1, MRPL39, PTRH2, RAB14, MRPL51, MRPL22, UQCRQ, PUF60, RAB31, TOMM40, MSLN, TOMM70A, NUPL1, SPCS2, PICALM, V
Protein Size: 124

Molecular Weight: 13 kDa

Gene ID: 8649

NCBI Accession: NM_021970, NP_068805

UniProt: Q9UHA4

Pathways: PI3K-Akt Signaling