SYK antibody (Middle Region)

Catalog No. ABIN2788676

The Rabbit Polyclonal anti-SYK antibody is suitable to detect SYK in samples from Human, Pig and Horse. It has been validated for WB.

Quick Overview for SYK antibody (Middle Region) (ABIN2788676)

Target: SYK (Spleen tyrosine Kinase (SYK))

Reactivity: Human, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SYK Antibody

Binding Specificity: Middle Region

Purpose: SYK Antibody - middle region

Sequence: RIKSYSFPKP GHRKSSPAQG NRQESTVSFN PYEPELAPWA ADKGPQREAL

Predicted Reactivity: Horse: 85%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against SYK. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61104-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Alternative Name: SYK

Background:

Background Information: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Spleen tyrosine kinase

Alternative Symbols: p72-Syk

Protein Name: Tyrosine-protein kinase SYK

Molecular Weight: 72kDa

Gene ID: 6850

NCBI Accession: NP_003168

UniProt: P43405

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling