RAG2 antibody (C-Term)
-
- Target See all RAG2 Antibodies
- RAG2 (Recombination Activating Gene 2 (RAG2))
-
Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This RAG2 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- HLSAGSNKYY CNEHVEIARA LHTPQRVLPL KKPPMKSLRK KGSGKILTPA
- Predicted Reactivity
- Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against RAG2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product RAG2 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 527 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- RAG2 (Recombination Activating Gene 2 (RAG2))
- Alternative Name
- RAG2 (RAG2 Products)
- Synonyms
- RAG-2 antibody, Rag-2 antibody, rag-2 antibody, zgc:136743 antibody, recombination activating 2 antibody, recombination activating gene 2 antibody, recombination activating gene 2 S homeolog antibody, RAG2 antibody, Rag2 antibody, rag2 antibody, rag2.S antibody
- Background
-
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.
Alias Symbols: RAG-2
Protein Interaction Partner: RAG1, VPRBP, DDB1, UBC, SKP2, IPO5, KPNA1, tax,
Protein Size: 527 - Molecular Weight
- 59 kDa
- Gene ID
- 5897
- NCBI Accession
- NM_000536, NP_000527
- UniProt
- P55895
- Pathways
- Chromatin Binding, Production of Molecular Mediator of Immune Response
-