NQO1 antibody (C-Term)

Catalog No. ABIN2788701

This Rabbit Polyclonal antibody specifically detects NQO1 in WB. It exhibits reactivity toward Human, Rat, Dog, Rabbit and Cow.

Quick Overview for NQO1 antibody (C-Term) (ABIN2788701)

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Reactivity: Human, Rat, Dog, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NQO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NQO1 Antibody

Binding Specificity: C-Term

Sequence: WKKRLENIWD ETPLYFAPSS LFDLNFQAGF LMKKEVQDEE KNKKFGLSVG

Predicted Reactivity: Cow: 86%, Dog: 79%, Human: 100%, Rabbit: 91%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against NQO1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NQO1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 274 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NQO1

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Alternative Name: NQO1

Background: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Protein Interaction Partner: UBC, FOS, NEDD8, SUMO1, NFE2L2, PARP1, BAG3, ITGA4, FN1, RPS10P5, POLDIP3, YTHDF1, RPS19, LAMB1, TP53, STUB1, ING1, DNAJB1, HSPA1A, NQO1, HSPA4,
Protein Size: 274

Molecular Weight: 31 kDa

Gene ID: 1728

NCBI Accession: NM_000903, NP_000894

UniProt: P15559