Endothelin 3 antibody (C-Term)

Catalog No. ABIN2788707

The Rabbit Polyclonal anti-Endothelin 3 antibody (ABIN2788707) specifically detects Endothelin 3 in WB. The antibody is reactive with Human and Pig samples.

Quick Overview for Endothelin 3 antibody (C-Term) (ABIN2788707)

Target: Endothelin 3 (EDN3)

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Endothelin 3 Antibody

Binding Specificity: C-Term

Purpose: EDN3 Antibody - C-terminal region

Sequence: LHFCTQTLDV SSNSRTAEKT DKEEEGKVRG ANRGLCQRRL KSRTNKASRL

Predicted Reactivity: Human: 100%, Pig: 85%

Characteristics: This is a rabbit polyclonal antibody against EDN3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EDN3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61174-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: EDN3

Background:

Background Information: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Gene Name: Endothelin 3

Alternative Symbols: ET3, ET-3, WS4B, HSCR4, PPET3

Protein Name: Endothelin-3

Molecular Weight: 24kDa

Gene ID: 1908

NCBI Accession: NP_996915

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones