KLRC1 antibody (N-Term)

Catalog No. ABIN2788755

This Rabbit Polyclonal antibody specifically detects KLRC1 in WB. It exhibits reactivity toward Human, Mouse and Guinea Pig.

Quick Overview for KLRC1 antibody (N-Term) (ABIN2788755)

Target: KLRC1 (Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))

Reactivity: Human, Mouse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLRC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KLRC1 Antibody

Binding Specificity: N-Term

Sequence: PKRQQRKPKG NKSSILATEQ EITYAELNLQ KASQDFQGND KTYHCKDLPS

Predicted Reactivity: Guinea Pig: 79%, Human: 100%, Mouse: 86%

Characteristics: This is a rabbit polyclonal antibody against KLRC1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 233 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KLRC1

Target: KLRC1 (Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))

Alternative Name: KLRC1

Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
Alias Symbols: CD159A, MGC13374, MGC59791, NKG2, NKG2A
Protein Interaction Partner: PMP22, MAL, KLRD1, PTPN6, PTPN11, HLA-E,
Protein Size: 233

Molecular Weight: 26 kDa

Gene ID: 3821

NCBI Accession: NM_002259, NP_002250

UniProt: P26715