IRAK4 antibody (C-Term)

Catalog No. ABIN2788803

The Rabbit Polyclonal anti-IRAK4 antibody (ABIN2788803) specifically detects IRAK4 in WB. The antibody is reactive with Human, Rat, Horse, Cow, Sheep and Guinea Pig samples.

Quick Overview for IRAK4 antibody (C-Term) (ABIN2788803)

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivity: Human, Rat, Horse, Cow, Sheep, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRAK4 Antibody

Binding Specificity: C-Term

Purpose: IRAK4 Antibody - C-terminal region

Sequence: TGLPAVDEHR EPQLLLDIKE EIEDEEKTIE DYIDKKMNDA DSTSVEAMYS

Predicted Reactivity: Cow: 77%, Guinea Pig: 91%, Horse: 92%, Human: 100%, Rat: 91%, Sheep: 77%

Characteristics: This is a rabbit polyclonal antibody against IRAK4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61431-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Alternative Name: IRAK4

Background:

Background Information: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Interleukin-1 receptor-associated kinase 4

Alternative Symbols: IPD1, IMD67, REN64, IRAK-4, NY-REN-64

Protein Name: Interleukin-1 receptor-associated kinase 4

Molecular Weight: 36kDa

Gene ID: 51135

NCBI Accession: NP_001138728

UniProt: Q9NWZ3

Pathways: NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades