PDGFC antibody (N-Term)

Catalog No. ABIN2788903

The Rabbit Polyclonal anti-PDGFC antibody is suitable to detect PDGFC in samples from Human, Mouse, Rat, Horse and Rabbit. It has been validated for WB.

Quick Overview for PDGFC antibody (N-Term) (ABIN2788903)

Target: PDGFC (Platelet-Derived Growth Factor C (PDGFC))

Reactivity: Human, Mouse, Rat, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDGFC Antibody

Binding Specificity: N-Term

Sequence: MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV

Predicted Reactivity: Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against Pdgfc. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Pdgfc

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDGFC

Target: PDGFC (Platelet-Derived Growth Factor C (PDGFC))

Alternative Name: Pdgfc

Background: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
Alias Symbols: 1110064L01Rik, AI647969, PDGF-C
Protein Size: 345

Molecular Weight: 39 kDa

Gene ID: 54635

NCBI Accession: NM_019971, NP_064355

UniProt: Q8CI19

Pathways: RTK Signaling, Platelet-derived growth Factor Receptor Signaling