KIF7 antibody (C-Term)

Catalog No. ABIN2788987

The Rabbit Polyclonal anti-KIF7 antibody is suitable to detect KIF7 in samples from Human, Mouse, Rat, Pig, Cow and Dog. It has been validated for WB.

Quick Overview for KIF7 antibody (C-Term) (ABIN2788987)

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Reactivity: Human, Mouse, Rat, Pig, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KIF7 Antibody

Binding Specificity: C-Term

Purpose: KIF7 Antibody - C-terminal region

Sequence: RDLVHAPLPL TWKRSSLCGE EQGSPEELRQ REAAEPLVGR VLPVGEAGLP

Predicted Reactivity: Cow: 92%, Dog: 79%, Human: 100%, Mouse: 77%, Pig: 100%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against KIF7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human KIF7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62009-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIF7

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Alternative Name: KIF7

Background:

Background Information: This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.

Gene Name: kinesin family member 7

Alternative Symbols: ACLS, AGBK, HLS2, JBTS12, UNQ340

Protein Name: kinesin-like protein KIF7

Molecular Weight: 91kDa

Gene ID: 374654

NCBI Accession: NP_940927

UniProt: Q2M1P5

Pathways: Hedgehog Signaling