TSEN2 antibody (C-Term)

Catalog No. ABIN2789135

This anti-TSEN2 antibody is a Rabbit Polyclonal antibody detecting TSEN2 in WB. Suitable for Human, Dog, Horse, Rabbit, Cow, Guinea Pig and Pig.

Quick Overview for TSEN2 antibody (C-Term) (ABIN2789135)

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Reactivity: Human, Dog, Horse, Rabbit, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TSEN2 Antibody

Binding Specificity: C-Term

Sequence: LRRPLSWKSL AALSRVSVNV SKELMLCYLI KPSTMTDKEM ESPECMKRIK

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Pig: 93%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against TSEN2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 465 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TSEN2

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Alternative Name: TSEN2

Background: This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: MGC2776, MGC4440, PCH2B, SEN2, SEN2L
Protein Interaction Partner: TSEN54, UBC, TBC1D2, PRPF39, POLD3, TBC1D4, TRIP10, USP8, POLD1, Clp1, RANBP10, TSEN15, TSEN34,
Protein Size: 465

Molecular Weight: 51 kDa

Gene ID: 80746

NCBI Accession: NM_025265, NP_079541

UniProt: Q8NCE0

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha