TSEN2 antibody

Catalog No. ABIN7231306

The Rabbit Polyclonal anti-TSEN2 antibody (ABIN7231306) specifically detects TSEN2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TSEN2 antibody (ABIN7231306)

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSEN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TSEN2 Antibody

Purpose: Rabbit Anti-SEN2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SEN2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SEN2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TSEN2

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Alternative Name: SEN2

Background: TRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2, HsSen2TSEN2 (TRNA Splicing Endonuclease Subunit 2) is a Protein Coding gene. Diseases associated with TSEN2 include Pontocerebellar Hypoplasia Type 2B and Pontocerebellar Hypoplasia, Type 2E. Among its related pathways are Gene Expression and tRNA processing. TSEN2 encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in TSEN2 have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for TSEN2.

Molecular Weight: 51kD

Gene ID: 80746

UniProt: Q8NCE0

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha