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TSEN2 antibody (AA 1-220)

TSEN2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7173540
  • Target See all TSEN2 Antibodies
    TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
    Binding Specificity
    • 14
    • 7
    • 2
    • 1
    • 1
    • 1
    AA 1-220
    Reactivity
    • 37
    • 17
    • 17
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 35
    • 2
    Rabbit
    Clonality
    • 37
    Polyclonal
    Conjugate
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TSEN2 antibody is un-conjugated
    Application
    • 36
    • 14
    • 13
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)
    Isotype
    IgG
    Top Product
    Discover our top product TSEN2 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:200-1:1000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
    Alternative Name
    TSEN2 (TSEN2 Products)
    Synonyms
    AU067695 antibody, RGD1309946 antibody, PCH2B antibody, SEN2 antibody, SEN2L antibody, tRNA splicing endonuclease subunit 2 antibody, TSEN2 antibody, Tsen2 antibody
    Background

    Background: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\\\'- and 3\\\'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\\\',3\\\'-cyclic phosphate and 5\\\'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5\\\'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\\\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\\\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

    Aliases: HsSen2 antibody, MGC2776 antibody, MGC4440 antibody, SEN2 antibody, SEN2_HUMAN antibody, SEN2L antibody, tRNA intron endonuclease Sen2 antibody, tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) antibody, tRNA splicing endonuclease subunit Sen2 antibody, tRNA-intron endonuclease sen2 antibody, tRNA-splicing endonuclease subunit Sen2 antibody, TSEN 2 antibody, TSEN2 antibody

    UniProt
    Q8NCE0
    Pathways
    Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha
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