ALOX5 antibody (C-Term)

Catalog No. ABIN2789351

The Rabbit Polyclonal anti-ALOX5 antibody is suitable to detect ALOX5 in samples from Human, Mouse, Rat, Cow, Rabbit, Dog, Horse and Guinea Pig. It has been validated for WB.

Quick Overview for ALOX5 antibody (C-Term) (ABIN2789351)

Target: ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOX5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALOX5 Antibody

Binding Specificity: C-Term

Sequence: FGQLFLGMYP EEHFIEKPVK EAMARFRKNL EAIVSVIAER NKKKQLPYYY

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against ALOX5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ALOX5

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ALOX5

Target: ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))

Alternative Name: ALOX5

Background: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: CEP57L1, NUTM1, SYCE1, CEP63, HHIPL2, COTL1, MAD1L1, REL, MEOX1, PIK3R1, DICER1, MAPKAPK2, LTC4S, ALOX5AP, APP, TGFBRAP1, GRB2, ACTB,
Protein Size: 617

Molecular Weight: 67 kDa

Gene ID: 240

NCBI Accession: NP_001243083

UniProt: B7ZLS0