HLA-C antibody (C-Term)

Catalog No. ABIN2789353

Product Details anti-HLA-C Antibody

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Binding Specificity: C-Term

Reactivity: Human, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPKTHVTHHP LSDHEATLRC WALGFYPAEI TLTWQRDGED QTQDTELVET

Predicted Reactivity: Human: 100%, Pig: 100%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against HLA-C. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 366 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HLA-C

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Alternative Name: HLA-C (HLA-C Products)

Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
Alias Symbols: D6S204, FLJ27082, HLA-Cw, HLA-Cw12, HLA-JY3, HLC-C, PSORS1
Protein Interaction Partner: UBC, RNF139, NEDD8, SUMO1, ADRB2, MMS19, YBX1, CDC25A, BATF2, PRRG4, env, TANK, FBXO6, PCK1, CXCR4, KIR2DL2, KIR2DL1, LILRB2, KIR2DL3, TAPBP, LILRB1, KIR2DS4, KIR2DS2, KIR2DS1, CD8A, TAP2, HSPA5, B2M, CALR, HLA-C,
Protein Size: 366

Molecular Weight: 38 kDa

Gene ID: 3107

NCBI Accession: NM_002117, NP_002108

UniProt: Q29960

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response