TES antibody (Middle Region)

Catalog No. ABIN2789357

The Rabbit Polyclonal anti-TES antibody is suitable to detect TES in samples from Human, Cow, Dog, Guinea Pig, Sheep, Horse and Pig. It has been validated for WB and IHC.

Quick Overview for TES antibody (Middle Region) (ABIN2789357)

Target: TES (Testis Derived Transcript (3 LIM Domains) (TES))

Reactivity: Human, Cow, Dog, Guinea Pig, Sheep, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TES antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TES Antibody

Binding Specificity: Middle Region

Purpose: TES Antibody - middle region

Sequence: PKQMNIPGGD RSTPAAVGAM EDKSAEHKRT QYSCYCCKLS MKEGDPAIYA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 91%, Horse: 79%, Human: 100%, Pig: 93%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against TES. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63068-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TES

Target: TES (Testis Derived Transcript (3 LIM Domains) (TES))

Alternative Name: TES

Background:

Background Information: Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.

Gene Name: Testis derived transcript (3 LIM domains)

Alternative Symbols: TESS, TESS-2

Protein Name: Testin

Molecular Weight: 47kDa

Gene ID: 26136

NCBI Accession: NP_056456

UniProt: Q9UGI8