Angiopoietin 1 antibody (N-Term)

Catalog No. ABIN2789374

The Rabbit Polyclonal anti-Angiopoietin 1 antibody is suitable to detect Angiopoietin 1 in samples from Human, Mouse, Rat, Dog, Cow, Horse, Rabbit and Pig. It has been validated for WB.

Quick Overview for Angiopoietin 1 antibody (N-Term) (ABIN2789374)

Target: Angiopoietin 1 (ANGPT1)

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiopoietin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Angiopoietin 1 Antibody

Binding Specificity: N-Term

Purpose: ANGPT1 Antibody - N-terminal region

Sequence: FAFLAAILTH IGCSNQRRSP ENSGRRYNRI QHGQCAYTFI LPEHDGNCRE

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ANGPT1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63106-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Angiopoietin 1

Target: Angiopoietin 1 (ANGPT1)

Alternative Name: ANGPT1

Background:

Background Information: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: Angiopoietin 1

Alternative Symbols: AGP1, AGPT, ANG1

Protein Name: Angiopoietin-1

Molecular Weight: 55kDa

Gene ID: 284

NCBI Accession: NP_001137

UniProt: Q15389

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process