SMN1 antibody (C-Term)

Catalog No. ABIN2789460

This Rabbit Polyclonal antibody specifically detects SMN1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Pig, Rabbit, Guinea Pig, Horse and Cow.

Quick Overview for SMN1 antibody (C-Term) (ABIN2789460)

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Guinea Pig, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMN1 Antibody

Binding Specificity: C-Term

Purpose: SMN1 Antibody - C-terminal region

Sequence: PPPPPICPDS LDDADALGSM LISWYMSGYH TGYYMGFRQN QKEGRCSHSL

Predicted Reactivity: Cow: 77%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 85%, Pig: 100%, Rabbit: 85%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against SMN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of SMN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63347-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMN1

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Alternative Name: SMN1

Background:

Background Information: SMN1 localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein.

Alternative Symbols: SMA, SMN, SMA1, SMA2, SMA3, SMA4, SMA@, SMNT, BCD541, GEMIN1, TDRD16A, T-BCD541

Protein Name: Survival motor neuron protein

Molecular Weight: 28kDa

Gene ID: 6606

NCBI Accession: NP_075012

UniProt: Q16637

Pathways: Ribonucleoprotein Complex Subunit Organization