EPM2A antibody (N-Term)

Catalog No. ABIN2789472

The Rabbit Polyclonal anti-EPM2A antibody (ABIN2789472) specifically detects EPM2A in WB. The antibody is reactive with Human, Rat, Cow, Dog, Pig and Rabbit samples.

Quick Overview for EPM2A antibody (N-Term) (ABIN2789472)

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Reactivity: Human, Rat, Cow, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPM2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EPM2A Antibody

Binding Specificity: N-Term

Purpose: EPM2A Antibody - N-terminal region

Sequence: ALALQEPGLW LGEVELAAEE AAQDGAEPGR VDTFWYKFLK REPGGELSWE

Predicted Reactivity: Cow: 100%, Dog: 90%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against EPM2A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63376-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for EPM2A

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Alternative Name: EPM2A

Background:

Background Information: This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants.

Gene Name: Epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

Alternative Symbols: EPM2, MELF

Protein Name: Laforin

Molecular Weight: 35kDa

Gene ID: 7957

NCBI Accession: NP_001018051

UniProt: O95278

Pathways: Cellular Glucan Metabolic Process