SOCS2 antibody (C-Term)

Catalog No. ABIN2789498

The Rabbit Polyclonal anti-SOCS2 antibody is suitable to detect SOCS2 in samples from Human, Rat, Mouse, Cow, Pig, Dog, Rabbit and Guinea Pig. It has been validated for WB.

Quick Overview for SOCS2 antibody (C-Term) (ABIN2789498)

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Reactivity: Human, Rat, Mouse, Cow, Pig, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SOCS2 Antibody

Binding Specificity: C-Term

Sequence: KQFDSVVHLI DYYVQMCKDK RTGPEAPRNG TVHLYLTKPL YTSAPSLQHL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SOCS2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 198 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Alternative Name: SOCS2

Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
Alias Symbols: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Protein Interaction Partner: Tceb1, CUL5, UBC, FLT3, ARFIP2, TPD52, PLA2G1B, BMI1, SOCS3, LCK, GHR, CCNC, RYBP, PTK2B, RNF7, TCEB2, EPOR, PTK2, PRLR, INSR, IGF1R, SOCS1,
Protein Size: 198

Molecular Weight: 22 kDa

Gene ID: 8835

NCBI Accession: NM_003877, NP_003868

UniProt: O14508

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus