IL5RA antibody (N-Term)

Catalog No. ABIN2789551

The Rabbit Polyclonal anti-IL5RA antibody is suitable to detect IL5RA in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for IL5RA antibody (N-Term) (ABIN2789551)

Target: IL5RA (Interleukin 5 Receptor, alpha (IL5RA))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL5RA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL5RA Antibody

Binding Specificity: N-Term

Purpose: IL5RA Antibody - N-terminal region

Sequence: GLAQVLLQWK PNPDQEQRNV NLEYQVKINA PKEDDYETRI TESKCVTILH

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 79%, Pig: 86%, Rat: 79%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against IL5RA. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63577-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL5RA

Target: IL5RA (Interleukin 5 Receptor, alpha (IL5RA))

Alternative Name: IL5RA

Background:

Targeted Subunit: alpha

Background Information: The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

Gene Name: Interleukin 5 receptor, alpha

Alternative Symbols: IL5R, CD125, CDw125, HSIL5R3

Protein Name: Interleukin-5 receptor subunit alpha

Molecular Weight: 46kDa

Gene ID: 3568

NCBI Accession: NP_783853

UniProt: Q01344

Pathways: JAK-STAT Signaling