Macrophage Scavenger Receptor 1 antibody (N-Term)

Catalog No. ABIN2789552

The Rabbit Polyclonal anti-Macrophage Scavenger Receptor 1 antibody (ABIN2789552) specifically detects Macrophage Scavenger Receptor 1 in WB. The antibody is reactive with Human, Pig, Dog, Horse and Cow samples.

Quick Overview for Macrophage Scavenger Receptor 1 antibody (N-Term) (ABIN2789552)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reactivity: Human, Pig, Dog, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Macrophage Scavenger Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Macrophage Scavenger Receptor 1 Antibody

Binding Specificity: N-Term

Purpose: MSR1 Antibody - N-terminal region

Sequence: VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN

Predicted Reactivity: Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%

Characteristics: This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63579-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: MSR1

Background:

Background Information: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gene Name: Macrophage scavenger receptor 1

Alternative Symbols: SRA, SR-A, CD204, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

Protein Name: Macrophage scavenger receptor types I and II

Molecular Weight: 50kDa

Gene ID: 4481

NCBI Accession: NP_619729

UniProt: P21757