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PDE6B antibody (C-Term)

PDE6B Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2789553
  • Target See all PDE6B Antibodies
    PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 14
    • 10
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig
    Host
    • 14
    • 1
    Rabbit
    Clonality
    • 15
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    This PDE6B antibody is un-conjugated
    Application
    • 12
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    RQHEHVIHLM DIAIIATDLA LYFKKRAMFQ KIVDESKNYQ DKKSWVEYLS
    Predicted Reactivity
    Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PDE6B. It was validated on Western Blot.
    Purification
    Affinity Purified
    Top Product
    Discover our top product PDE6B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 854 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))
    Alternative Name
    PDE6B (PDE6B Products)
    Synonyms
    CSNB3 antibody, CSNBAD2 antibody, PDEB antibody, RP40 antibody, rd1 antibody, PDBS antibody, RCD-1 antibody, Pdeb antibody, r antibody, rd antibody, rd-1 antibody, rd10 antibody, phosphodiesterase 6B antibody, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide antibody, PDE6B antibody, Pde6b antibody
    Background
    Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: CSNB3, CSNBAD2, PDEB, RP40, rd1
    Protein Interaction Partner: PPP1CC,
    Protein Size: 854
    Molecular Weight
    98 kDa
    Gene ID
    5158
    NCBI Accession
    NM_001145292, NP_001138764
    UniProt
    E7ETT3
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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