Integrin beta 3 antibody (N-Term)

Catalog No. ABIN2789560

The Rabbit Polyclonal anti-Integrin beta 3 antibody is suitable to detect Integrin beta 3 in samples from Human, Rat, Cow, Dog, Rabbit, Sheep, Horse and Guinea Pig. It has been validated for WB.

Quick Overview for Integrin beta 3 antibody (N-Term) (ABIN2789560)

Target: Integrin beta 3 (ITGB3)

Reactivity: Human, Rat, Cow, Dog, Rabbit, Sheep, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Integrin beta 3 Antibody

Binding Specificity: N-Term

Purpose: ITGB3 Antibody - N-terminal region

Sequence: PLGSPRCDLK ENLLKDNCAP ESIEFPVSEA RVLEDRPLSD KGSGDSSQVT

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Rabbit: 93%, Rat: 92%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against ITGB3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63597-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: ITGB3

Background:

Background Information: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Gene Name: Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Alternative Symbols: GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16

Protein Name: Integrin beta-3

Molecular Weight: 84kDa

Gene ID: 3690

NCBI Accession: NP_000203

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex