PLAU antibody (C-Term)
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- Target See all PLAU Antibodies
- PLAU (Plasminogen Activator, Urokinase (PLAU))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rabbit, Horse, Saccharomyces cerevisiae
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PLAU antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- CSLQGRMTLT GIVSWGRGCA LKDKPGVYTR VSHFLPWIRS HTKEENGLAL
- Predicted Reactivity
- Horse: 86%, Human: 100%, Rabbit: 86%, Yeast: 100%
- Characteristics
- This is a rabbit polyclonal antibody against PLAU. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product PLAU Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 431 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PLAU (Plasminogen Activator, Urokinase (PLAU))
- Alternative Name
- PLAU (PLAU Products)
- Synonyms
- PLAU antibody, u-PA antibody, ATF antibody, BDPLT5 antibody, QPD antibody, UPA antibody, URK antibody, uPA antibody, UPAM antibody, plasminogen activator, urokinase antibody, urokinase-type plasminogen activator antibody, PLAU antibody, CpipJ_CPIJ002131 antibody, CpipJ_CPIJ006543 antibody, CpipJ_CPIJ013396 antibody, CpipJ_CPIJ013623 antibody, Plau antibody
- Background
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This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alias Symbols: ATF, UPA, URK, u-PA, QPD, BDPLT5
Protein Interaction Partner: TEX101, UBC, PLAUR, SUMO1, NEDD8, CEBPG, ELAVL1, MYC, BTK, ALAS1, SCAMP5, PDGFC, ST14, SERPINA5, LRP2, SERPINF2, F2, SERPINB2, PLAT, SERPINE1, PLG, SERPINB6, IGF2R, HGF, NID1, CTSL, CTSB, MAP2K1, HRAS, SERPINE2,
Protein Size: 431 - Molecular Weight
- 28 kDa
- Gene ID
- 5328
- NCBI Accession
- NM_002658, NP_002649
- UniProt
- P00749
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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