GIPR antibody (N-Term)

Catalog No. ABIN2789673

This Rabbit Polyclonal antibody specifically detects GIPR in WB. It exhibits reactivity toward Human, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse and Pig.

Quick Overview for GIPR antibody (N-Term) (ABIN2789673)

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Reactivity: Human, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIPR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GIPR Antibody

Binding Specificity: N-Term

Purpose: GIPR Antibody - N-terminal region

Sequence: LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSVAA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GIPR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human GIPR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63934-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GIPR

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Alternative Name: GIPR

Background:

Background Information: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.

Gene Name: gastric inhibitory polypeptide receptor

Alternative Symbols: PGQTL2

Protein Name: gastric inhibitory polypeptide receptor

Molecular Weight: 47kDa

Gene ID: 2696

NCBI Accession: NP_000155

UniProt: B7WP14

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling