GIPR antibody (N-Term)

Catalog No. ABIN2789673

Product Details anti-GIPR Antibody

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Binding Specificity: N-Term

Reactivity: Human, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIPR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSVAA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GIPR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human GIPR

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GIPR

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Alternative Name: GIPR (GIPR Products)

Synonyms: GIPR antibody, PGQTL2 antibody, GIP-R antibody, Gm1081 antibody, Gm160 antibody, Gippr antibody, RATGIPPR antibody, gastric inhibitory polypeptide receptor antibody, glucagon receptor antibody, GIPR antibody, LOC100303705 antibody, Gipr antibody

Background: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
Alias Symbols: PGQTL2
Protein Size: 430

Molecular Weight: 47 kDa

Gene ID: 2696

NCBI Accession: NM_000164, NP_000155

UniProt: B7WP14

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling