Melatonin Receptor 1B antibody (N-Term)

Catalog No. ABIN2789720

This Rabbit Polyclonal antibody specifically detects Melatonin Receptor 1B in WB. It exhibits reactivity toward Human, Pig and Rabbitand has been mentioned in 1 publication.

Quick Overview for Melatonin Receptor 1B antibody (N-Term) (ABIN2789720)

Target: Melatonin Receptor 1B (MTNR1B)

Reactivity: Human, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Melatonin Receptor 1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Melatonin Receptor 1B Antibody

Binding Specificity: N-Term

Sequence: SFANCCEAGG WAVRPGWSGA GSARPSRTPR PPWVAPALSA VLIVTTAVDV

Predicted Reactivity: Human: 100%, Pig: 79%, Rabbit: 79%

Characteristics: This is a rabbit polyclonal antibody against MTNR1B. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 362 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Melatonin Receptor 1B antibody (ABIN2789720)

Santoro, Mori, Marani, Grasso, Cambria, Blandino, Muti, Strano: "Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation." in: Carcinogenesis, Vol. 34, Issue 5, pp. 1051-61, (2013) (PubMed).

Target Details for Melatonin Receptor 1B

Target: Melatonin Receptor 1B (MTNR1B)

Alternative Name: MTNR1B

Background: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
Alias Symbols: FGQTL2, MEL-1B-R, MT2
Protein Interaction Partner: GNAI1, GPR50, ITM2C, HNRNPA0, GNB4, PPM1G, PI4KA, PDIA6, VPS35, IRS4, COPA, CTNND1, MTNR1B, MTNR1A, FLNA, YWHAQ, GNB1, GNAI3, GNAI2, HSPA5, CANX,
Protein Size: 362

Molecular Weight: 40 kDa

Gene ID: 4544

NCBI Accession: NM_005959, NP_005950

UniProt: P49286